Article

Unconstrained Precision Mitochondrial Genome Editing with αDdCBEs

2024-05-13

Abstract excerpt

<h4>ABSTRACT</h4> DddA-derived cytosine base editors (DdCBEs) enable the targeted introduction of C•G-to-T•A conversions in mitochondrial DNA (mtDNA). DdCBEs are often deployed as pairs, with each arm comprised of a transcription activator-like effector (TALE), a split double-stranded DNA deaminase half, and a uracil glycosylase inhibitor. This pioneering technology has helped improve our understanding of cellula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0cb051de-2b74-54d0-a6b8-96bfd54bf868
DOI: 10.1101/2024.05.13.593977

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unconstrained Precision Mitochondrial Genome Editing with αDdCBEsDOI 10.1101/2024.05.13.593977Read

Enhanced C-To-T and A-To-G Base Editing in Mitochondrial DNA with Engineered DdCBE and TALED.Semantic proximity Read

Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNASemantic proximity Read

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNASemantic proximity Read

Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors.Semantic proximity Read

Structure-guided engineering of AI-derived adenine base editors for nuclear and mitochondrial DNA editing.Semantic proximity Read

Base editing in human cells with monomeric DddA-TALE fusion deaminases.Semantic proximity Read

Advances in mitochondrial DNA base editing technology.Semantic proximity Read

A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility.Semantic proximity Read

An engineered mitoCBE facilitates efficient mitochondrial DNA editing and modified mitochondrial transfer.Semantic proximity Read

Reducing off-target effects of DdCBEs by reversing amino acid charge near DNA interaction sitesSemantic proximity Read

Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing.Semantic proximity Read

Mitochondrial base editor induces substantial nuclear off-target mutations.Semantic proximity Read