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Article

Base editing in human cells with monomeric DddA-TALE fusion deaminases.

Nature communications - 12 Jul 2022

Mok Young Geun, Lee Ji Min, Chung Eugene, Lee Jaesuk, Lim Kayeong, Cho Sung-Ik, Kim Jin-Soo

Abstract excerpt

Inter-bacterial toxin DddA-derived cytosine base editors (DdCBEs) enable targeted C-to-T conversions in nuclear and organellar DNA. DddAtox, the deaminase catalytic domain derived from Burkholderia cenocepacia, is split into two inactive halves to avoid its cytotoxicity in eukaryotic cells, when fused to transcription activator-like effector (TALE) DNA-binding proteins to make DdCBEs. As a result, DdCBEs function...

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Identifiers

PMID: 35821233
DOI: 10.1038/s41467-022-31745-y
PMCID: PMC9276701

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