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Article

Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors.

Nature biotechnology - 1 Mar 2023

Lee Seonghyun, Lee Hyunji, Baek Gayoung, Kim Jin-Soo

Abstract excerpt

Bacterial toxin DddA-derived cytosine base editors (DdCBEs)-composed of split DddAtox (a cytosine deaminase specific to double-stranded DNA), custom-designed TALE (transcription activator-like effector) DNA-binding proteins, and a uracil glycosylase inhibitor-enable mitochondrial DNA (mtDNA) editing in human cells, which may pave the way for therapeutic correction of pathogenic mtDNA mutations in patients. The...

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Identifiers

PMID: 36229610
DOI: 10.1038/s41587-022-01486-w
PMCID: PMC10017512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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