Article
Efficient base editing with high precision in rabbits using YFE-BE4max.
Cell death & disease - 20 Jan 2020
Liu Zhiquan, Chen Siyu, Shan Huanhuan, Jia Yingqi, Chen Mao, Song Yuning, Lai Liangxue, Li Zhanjun
Abstract excerpt
Cytidine base editors, composed of a cytidine deaminase fused to Cas9 nickase, enable efficient C-to-T conversion in various organisms. However, current base editors suffer from severe trade-off between editing efficiency and precision. Here, based on rationally mutated cytidine deaminase domain, we develop a new base editor, YFE-BE4max, effectively narrow the editing width to as little as approximately three...
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