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Article

Base editing of organellar DNA with programmable deaminases.

Nature reviews. Molecular cell biology - 1 Jan 2024

Kim Jin-Soo, Chen Jia

Abstract excerpt

Mitochondria and chloroplasts are organelles that include their own genomes, which encode key genes for ATP production and carbon dioxide fixation, respectively. Mutations in mitochondrial DNA can cause diverse genetic disorders and are also linked to ageing and age-related diseases, including cancer. Targeted editing of organellar DNA should be useful for studying organellar genes and developing novel...

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PMID: 37794167
DOI: 10.1038/s41580-023-00663-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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