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Reducing off-target effects of DdCBEs by reversing amino acid charge near DNA interaction sites

10 Sept 2024

Abstract excerpt

DddA tox -derived cytosine base editors (DdCBEs) can mediate precise, CRISPR-independent editing of mitochondrial DNA (mtDNA), but were recently shown to potentially introduce extensive and non-trivial off-target effects throughout the genome, 1 , 2 presenting a significant obstacle for research applications and an obvious safety issue for use in clinical therapies of hereditary mitochondrial disorders. Here,...

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PMID: 39256612
DOI: 10.1038/s41422-024-01028-w

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