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Article

Genome-wide screening for genetic variants in polyadenylation signal (PAS) sites in mouse selection lines for fatness and leanness.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2023

Šimon Martin, Mikec Špela, Morton Nicholas M, Atanur Santosh S, Konc Janez, Horvat Simon, Kunej Tanja

Abstract excerpt

Alternative polyadenylation (APA) determines mRNA stability, localisation, translation and protein function. Several diseases, including obesity, have been linked to APA. Studies have shown that single nucleotide polymorphisms in polyadenylation signals (PAS-SNPs) can influence APA and affect phenotype and disease susceptibility. However, these studies focussed on associations between single PAS-SNP alleles with...

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Identifiers

PMID: 36414820
DOI: 10.1007/s00335-022-09967-8
PMCID: PMC9684942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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