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Article

Associations of HLA and drug-metabolizing enzyme genes in co-trimoxazole-induced severe cutaneous adverse reactions.

Drug metabolism and pharmacokinetics - 1 Dec 2022

Nakkam Nontaya, Saksit Niwat, Konyoung Parinya, Amornpinyo Warayuwadee, Khunarkornsiri Usanee, Purimart Danklai, Pattanacheewapull Oranuch, Naewla Tanaporn, Wattanachai Pansakon, Khaeso Kanyarat, Chumworathayi Pansu, Tassaneeyakul Wichittra

Abstract excerpt

Co-trimoxazole is mainly used as a first-line drug for treatment and prophylaxis against Pneumocystis jiroveci pneumonia. This drug, however, has been reported as the most common causative drug for severe cutaneous adverse reactions (SCARs). This study aimed to extensively elucidate the associations between genetic polymorphisms of HLA class I and genes involved in bioactivation and detoxification of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36379177
DOI: 10.1016/j.dmpk.2022.100480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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