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Article

HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review.

Journal of immunology research - 1 Jan 2014

Cheng Chi-Yuan, Su Shih-Chi, Chen Chi-Hua, Chen Wei-Li, Deng Shin-Tarng, Chung Wen-Hung

Abstract excerpt

T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies...

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Alleles
Allopurinol
Carbamazepine
Dideoxynucleosides
Gene Expression

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Stevens-Johnson Syndrome

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PMID: 24901010
DOI: 10.1155/2014/565320
PMCID: PMC4034438

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