HLA-B Alleles With Shared Peptide Binding Specificities Define Global Risk of Co-trimoxazole-Induced Severe Cutaneous Adverse Drug Reactions.

doi:10.1016/j.jaip.2025.08.001

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Article

HLA-B Alleles With Shared Peptide Binding Specificities Define Global Risk of Co-trimoxazole-Induced Severe Cutaneous Adverse Drug Reactions.

The journal of allergy and clinical immunology. In practice - 1 Nov 2025

Li Yueran, Gibson Andrew, Saeed Hajirah N, Ashraf Mohammadali, Li Danmeng, Ostrov David A, Krantz Matthew S, Mallal Simon A, Alves Eric, Chopra Abha, Choo Linda, Dodiuk-Gad Roni P, Kaffenberger Benjamin, Drucker Aaron M, Goh Michelle S, Ergen Elizabeth, Micheletti Robert, Rosenbach Misha, Martin-Pozo Michelle D, Gangula Rama, Williams Elizabeth A, Yu Alexis, O'Connor April, Mahan Kelby, Kwan James T, Metcalfe Derek, Rashad Ramy, Shanbhag Swapna S, Tahboub Mohammed Ali, Pedretti Sarah, Choshi Phuti, Chimbetete Tafadzwa, Selim Rose, James Ian, Trubiano Jason A, Lehloenya Rannakoe, Peter Jonny G, Phillips Elizabeth J

Abstract excerpt

BACKGROUND: Co-trimoxazole is a leading global cause of severe cutaneous adverse drug reactions (SCAR) including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Co-trimoxazole-induced SCAR are associated with HLA class I alleles including HLA-B∗13:01 and HLA-B∗38:02 in Southeast Asian (SEA) populations. However, the global...

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PMID: 40784610
DOI: 10.1016/j.jaip.2025.08.001
PMCID: PMC12541198

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