Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians.

doi:10.1016/j.jaci.2020.08.003

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Article

Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians.

The Journal of allergy and clinical immunology - 1 Apr 2021

Wang Chuang-Wei, Tassaneeyakul Wichittra, Chen Chun-Bing, Chen Wei-Ti, Teng Yu-Chuan, Huang Cheng-Yang, Sukasem Chonlaphat, Lu Chun-Wei, Lee Yun-Shien, Choon Siew-Eng, Nakkam Nontaya, Hui Rosaline Chung-Yee, Huang Yen-Hua, Chang Ya-Ching, Lin Yang Yu-Wei, Chang Chee-Jen, Chiu Tsu-Man, Chantratita Wasun, Konyoung Parinya, Lee Chaw-Ning, Klaewsongkram Jettanong, Rerkpattanapipat Ticha, Amornpinyo Warayuwadee, Saksit Niwat, Rerknimitr Pawinee, Huang Yu Huei, Lin Shang-Hung, Hsu Chao-Kai, Chan Cheng-Chi, Lin Yu-Jr, Hung Shuen-Iu, Chung Wen-Hung

Abstract excerpt

BACKGROUND: Co-trimoxazole, a sulfonamide antibiotic, is used to treat a variety of infections worldwide, and it remains a common first-line medicine for prophylaxis against Pneumocystis jiroveci pneumonia. However, it can cause severe cutaneous adverse reaction (SCAR), including Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. The pathomechanism of...

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PMID: 32791162
DOI: 10.1016/j.jaci.2020.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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