Article

HLA-B Alleles with Shared Peptide Binding Specificities Define Global Risk of Cotrimoxazole-induced SCAR

2025-05-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Co-trimoxazole is a leading global cause of severe cutaneous adverse drug reactions (SCAR) including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Co-trimoxazole-induced SCAR are associated with HLA class I alleles including HLA-B*13:01 and HLA-B*38:02 in Southeast Asian (SEA) populations. Howev...

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Literature Corpus work: dd99478d-26cd-575b-b7a5-7f021c1d934a
DOI: 10.1101/2025.05.28.25328237

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