Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes.

doi:10.1002/cpt.1915

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Article

Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes.

Clinical pharmacology and therapeutics - 1 Nov 2020

Sukasem Chonlaphat, Pratoomwun Jirawat, Satapornpong Patompong, Klaewsongkram Jettanong, Rerkpattanapipat Ticha, Rerknimitr Pawinee, Lertpichitkul Pattamon, Puangpetch Apichaya, Nakkam Nontaya, Konyoung Parinya, Khunarkornsiri Usanee, Disphanurat Wareeporn, Srisuttiyakorn Chutika, Pattanacheewapull Oranuch, Kanjanawart Sirimas, Kongpan Thachanan, Chumworathayi Pansu, Saksit Niwat, Bruminhent Jackrapong, Tassaneeyakul Wichittra, Chantratita Wasun, Pirmohamed Munir

Abstract excerpt

Co-trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This case-control study was conducted to investigate the involvement between genetic variants of human leukocyte antigen (HLA) and CYP2C9 in CTX-induced SCARs, including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS) in Thai patients. Thirty...

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PMID: 32452529
DOI: 10.1002/cpt.1915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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