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Article

Human Leukocyte Antigens and Sulfamethoxazole/Cotrimoxazole-Induced Severe Cutaneous Adverse Reactions: A Systematic Review and Meta-Analysis.

JAMA dermatology - 1 May 2024

Wu Po-Chien, Chen Wei-Ti, Huang I-Hsin, Chen Chun-Bing, Wang Chuang-Wei, Tai Cheng-Chen, Chung Wen-Hung, Chi Ching-Chi

Abstract excerpt

Importance: Sulfamethoxazole (SMX) and cotrimoxazole (CTX), a fixed-dose combination of SMX and trimethoprim in a 5:1 ratio, are antibacterial sulfonamides commonly used for treating various diseases. A substantial prevalence of severe cutaneous adverse reactions (SCARs) following the administration of these drugs has been reported. However, the association between human leukocyte antigen (HLA) genotypes and...

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Identifiers

PMID: 38568509
DOI: 10.1001/jamadermatol.2024.0210
PMCID: PMC10993165

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