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Article

COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection.

PLoS genetics - 1 Nov 2022

Wang Yuxuan, Guga Suri, Wu Kejia, Khaw Zoe, Tzoumkas Konstantinos, Tombleson Phil, Comeau Mary E, Langefeld Carl D, Cunninghame Graham Deborah S, Morris David L, Vyse Timothy J

Abstract excerpt

Genome wide association studies show there is a genetic component to severe COVID-19. We find evidence that the genome-wide genetic association signal with severe COVID-19 is correlated with that of systemic lupus erythematosus (SLE), having formally tested this using genetic correlation analysis by LD score regression. To identify the shared associated loci and gain insight into the shared genetic effects, using...

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Identifiers

PMID: 36327221
DOI: 10.1371/journal.pgen.1010253
PMCID: PMC9632821

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