A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.

doi:10.1371/journal.pgen.1002406

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Article

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.

PLoS genetics - 1 Dec 2011

Ramos Paula S, Criswell Lindsey A, Moser Kathy L, Comeau Mary E, Williams Adrienne H, Pajewski Nicholas M, Chung Sharon A, Graham Robert R, Zidovetzki Raphael, Kelly Jennifer A, Kaufman Kenneth M, Jacob Chaim O, Vyse Timothy J, Tsao Betty P, Kimberly Robert P, Gaffney Patrick M, Alarcón-Riquelme Marta E, Harley John B, Langefeld Carl D

Abstract excerpt

In spite of the well-known clustering of multiple autoimmune disorders in families, analyses of specific shared genes and polymorphisms between systemic lupus erythematosus (SLE) and other autoimmune diseases (ADs) have been limited. Therefore, we comprehensively tested autoimmune variants for association with SLE, aiming to identify pleiotropic genetic associations between these diseases. We compiled a list of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22174698
DOI: 10.1371/journal.pgen.1002406
PMCID: PMC3234215

Genes

ITGAM
ITGAX
OLIG3
TNFAIP3
TNFSF4
VTCN1

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