Article
Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.
PLoS genetics - 1 Oct 2011
Cunninghame Graham Deborah S, Morris David L, Bhangale Tushar R, Criswell Lindsey A, Syvänen Ann-Christine, Rönnblom Lars, Behrens Timothy W, Graham Robert R, Vyse Timothy J
Abstract excerpt
Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ~8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association studies, which identified loci with a strong effect (OR>1.3). In order to identify additional genes...
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