Article

Cross-disorder genetic analysis of immune diseases reveals distinct disease groups and associated genes that converge on common pathogenic pathways

2022-10-06

Abstract excerpt

Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci associated with immune-mediated diseases, many of which are shared across multiple diseases. To assess the extent of the genetic sharing across nine immune-mediated diseases we applied genomic structural equation modelling (genomic SEM) to GWAS data. By modelling the genetic covariance between these diseases, we identified three di...

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Literature Corpus work: e9122eae-8654-535f-9080-a4ce1cb2ff79
DOI: 10.1101/2022.10.03.510292

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