Article
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms.
Nature genetics - 1 May 2024
Lincoln Matthew R, Connally Noah, Axisa Pierre-Paul, Gasperi Christiane, Mitrovic Mitja, van Heel David, Wijmenga Cisca, Withoff Sebo, Jonkers Iris H, Padyukov Leonid, Rich Stephen S, Graham Robert R, Gaffney Patrick M, Langefeld Carl D, Vyse Timothy J, Hafler David A, Chun Sung, Sunyaev Shamil R, Cotsapas Chris
Abstract excerpt
Autoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining whether the same allele is responsible, indicating a shared underlying mechanism. Here, using a collection of 129,058 cases and controls across 6 diseases, we show that ~40% of overlapping associations are...
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