Article

Disentangling the common genetic architecture and causality of rheumatoid arthritis and systemic lupus erythematosus with COVID-19 outcomes: genome-wide cross trait analysis and bi-directional Mendelian randomization study

2022-06-14

Abstract excerpt

COVID-19 may cause a dysregulation of the immune system and has complex relationships with multiple autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). However, little is known about their common genetic architecture. We analysed summary-level genetic data from the latest COVID-19 host genetics consortium and consortia on RA and SLE to examine the shared genetic etiolog...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77b1215e-ccb9-50ff-982d-a5691d239df9
DOI: 10.1101/2022.06.10.22276268

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disentangling the common genetic architecture and causality of rheumatoid arthritis and systemic lupus erythematosus with COVID-19 outcomes: genome-wide cross trait analysis and bi-directional Mendelian randomization studyDOI 10.1101/2022.06.10.22276268Read

Disentangling the common genetic architecture and causality of rheumatoid arthritis and systemic lupus erythematosus with COVID-19 outcomes: Genome-wide cross trait analysis and bidirectional Mendelian randomization study.Semantic proximity Read

COVID-19 and systemic lupus erythematosus genetics: A balance between autoimmune disease risk and protection against infection.Semantic proximity Read

A second update on mapping the human genetic architecture of COVID-19Semantic proximity Read

Mapping the human genetic architecture of COVID-19 by worldwide meta-analysisSemantic proximity Read

Mapping the human genetic architecture of COVID-19.Semantic proximity Read

Shared genetic etiology and causality between COVID-19 and venous thromboembolism: evidence from genome-wide cross trait analysis and bi-directional Mendelian randomization studySemantic proximity Read

Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative AnalysesSemantic proximity Read

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalizationSemantic proximity Read

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.Semantic proximity Read

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization.Semantic proximity Read

Novel Genomic Risk Loci shared between Juvenile Idiopathic Arthritis and other HLA-associated Autoimmune DiseasesSemantic proximity Read