Article

Joint analysis reveals shared autoimmune disease associations and identifies common mechanisms

2021-05-18

Abstract excerpt

Autoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining if the same allele is responsible, indicating a shared underlying mechanism. Using a collection of 129,058 cases and controls across six diseases, we show that ∼40% of overlapping associations are due to the...

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Literature Corpus work: 10401d64-feaa-59a7-a345-ed0db823967d
DOI: 10.1101/2021.05.13.21257044

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