Article
Identification of ST3AGL4, MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning.
Annals of the rheumatic diseases - 1 Jul 2018
Wang Yong-Fei, Zhang Yan, Zhu Zhengwei, Wang Ting-You, Morris David L, Shen Jiangshan Jane, Zhang Huoru, Pan Hai-Feng, Yang Jing, Yang Sen, Ye Dong-Qing, Vyse Timothy J, Cui Yong, Zhang Xuejun, Sheng Yujun, Lau Yu Lung, Yang Wanling
Abstract excerpt
OBJECTIVES: Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic component in its pathogenesis. Through genome-wide association studies (GWAS), we recently identified 10 novel loci associated with SLE and uncovered a number of suggestive loci requiring further validation. This study aimed to validate those loci in independent cohorts and evaluate the role of SLE genetics in...
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