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Article

Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus.

Nature communications - 7 Feb 2023

Khunsriraksakul Chachrit, Li Qinmengge, Markus Havell, Patrick Matthew T, Sauteraud Renan, McGuire Daniel, Wang Xingyan, Wang Chen, Wang Lida, Chen Siyuan, Shenoy Ganesh, Li Bingshan, Zhong Xue, Olsen Nancy J, Carrel Laura, Tsoi Lam C, Jiang Bibo, Liu Dajiang J

Abstract excerpt

Systemic lupus erythematosus is a heritable autoimmune disease that predominantly affects young women. To improve our understanding of genetic etiology, we conduct multi-ancestry and multi-trait meta-analysis of genome-wide association studies, encompassing 12 systemic lupus erythematosus cohorts from 3 different ancestries and 10 genetically correlated autoimmune diseases, and identify 16 novel loci. We also...

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Identifiers

PMID: 36750564
DOI: 10.1038/s41467-023-36306-5
PMCID: PMC9905560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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