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Article

Discovery of core genes for systemic lupus erythematosus via genome-wide aggregated trans-effects analysis.

Genes and immunity - 1 Oct 2025

Iakovliev Andrii, Castellini-Pérez Olivia, Erabadda Buddhiprabha, Martín Javier, Barturen Guillermo, McKeigue Paul M, Carnero-Montoro Elena, Alarcón-Riquelme Marta E, Spiliopoulou Athina

Abstract excerpt

The "omnigenic" hypothesis postulates that the polygenic effects of common variants on a typical complex trait coalesce on relatively few core genes through trans-effects on their expression. Our aim was to identify core genes for systemic lupus erythematosus (SLE) by testing for association with genome-wide aggregated trans-effects (GATE) scores for gene expression in a large genetic dataset (5267/4909 SLE...

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Identifiers

PMID: 40903491
DOI: 10.1038/s41435-025-00352-4
PMCID: PMC12527927

Genes

CD27
CD5L
CXCL13
LAG3
PDCD1
SIGLEC1
TNFRSF13B
TNFRSF17
TNFRSF9

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