Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of primary cilia promotes inflammation and carcinogenesis

25 Oct 2022

Abstract excerpt

Primary cilia (PC) are important signaling hubs, and we here explored their role in colonic pathology. In the colon, PC are mostly present on fibroblasts, and exposure of mice to either chemically induced colitis‐associated colon carcinogenesis (CAC) or dextran sodium sulfate (DSS)‐induced acute colitis decreases PC numbers. We generated conditional knockout mice with reduced numbers of PC on colonic fibroblasts....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bladder and Urothelial Cancer Treatments
Share to Epigenetics and DNA Methylation
Share to Genetic and Kidney Cyst Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36281991
DOI: 10.15252/embr.202255687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of primary cilia promotes inflammation and carcinogenesisPMID 36281991Read ↗

Partial loss of colonic primary cilia promotes inflammation and carcinogenesisSemantic proximity Read ↗

RNF43 is a gatekeeper for colitis-associated cancerSemantic proximity Read ↗

Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model.Semantic proximity Read ↗

Coronin1A regulates tumor microenvironment in colitis-associated colorectal cancer in a SUMO-dependent waySemantic proximity Read ↗

Epithelial dysfunction as a driver of symptoms in gastrointestinal disordersSemantic proximity Read ↗

Genetic Mouse Models with Intestinal-Specific Tight Junction Deletion Resemble an Ulcerative Colitis Phenotype.Semantic proximity Read ↗

Epithelial CRL4 DCAF2 is critical for maintaining intestinal homeostasis by regulating the proliferation and repair of intestinal epithelial cellsSemantic proximity Read ↗

Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) mice.Semantic proximity Read ↗

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22Semantic proximity Read ↗

PKN2 regulates cell-junctions to limit colitisSemantic proximity Read ↗

Phenotypic Analysis of Mice with Conditional Knockout of PPP2CA in Colonic Tissues.Semantic proximity Read ↗

Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.