Article

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

2018-12-01

Abstract excerpt

Interleukin-22 (IL-22) is critical in maintaining homeostasis in the intestine by regulating the balance between pathogenic and commensal bacteria. IL-22 also promotes wound healing and tissue regeneration, which can support the growth of colorectal tumours. Mutations in the tumour suppressor Adenomatous Polyposis Coli gene ( Apc ) cause intestinal tumorigenesis and are a major driver of familial colorectal cance...

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Literature Corpus work: 421b0524-2fa1-5764-a99f-71f13989be2d
DOI: 10.1101/479972

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