Article

Epithelial CRL4 DCAF2 is critical for maintaining intestinal homeostasis by regulating the proliferation and repair of intestinal epithelial cells

2022-12-09

Abstract excerpt

<h4>Background: </h4> & Aims: Inflammatory bowel disease (IBD) is becoming more and more popular in the whole wide world. Intestinal epithelial barrier dysfunction is an important step to IBD while the mechanisms are not fully understood. This study aimed to clarify the function of CRL4 DCAF2 , an E3 ligase, in maintaining intestinal homeostasis. <h4>Methods: </h4>: Expression of CRL4 DCAF2 was evaluated in colon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a05631f1-d879-50b7-bd15-68c48fe4a7c4
DOI: 10.21203/rs.3.rs-2291247/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epithelial CRL4 DCAF2 is critical for maintaining intestinal homeostasis by regulating the proliferation and repair of intestinal epithelial cellsDOI 10.21203/rs.3.rs-2291247/v1Read

NDRG2 Regulates Adherens Junction Integrity to Restrict Colitis and TumorigenesisSemantic proximity Read

Molecular pathways driving disease-specific alterations of intestinal epithelial cells.Semantic proximity Read

Loss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid HandlingSemantic proximity Read

Coronin1A regulates tumor microenvironment in colitis-associated colorectal cancer in a SUMO-dependent waySemantic proximity Read

The Histone Methyltransferase SETD2 Modulates Oxidative Stress to Attenuate Colonic Inflammation and Tumorigenesis in MiceSemantic proximity Read

Identification of genes critical for inducing ulcerative colitis and exploring their tumorigenic potential in human colorectal carcinomaSemantic proximity Read

The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancerSemantic proximity Read

Identification and immunoinfiltration analysis of key genes in ulcerative colitis using WGCNASemantic proximity Read

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn’s DiseaseSemantic proximity Read

The Role of E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe?Semantic proximity Read

RNF43 is a gatekeeper for colitis-associated cancerSemantic proximity Read

PRKAR2A‐derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis‐associated colorectal cancerSemantic proximity Read