Article

RNF43 is a gatekeeper for colitis-associated cancer

2024-02-01

Abstract excerpt

<h4>SUMMARY</h4> Somatic mutations in the tumor suppressor Ring finger protein 43 ( RNF43 ) were frequently found in colitis-associated cancer (CAC) and related to the duration of chronic inflammation, but their significance in inflammation and inflammation-associated carcinogenesis remained elusive. We assessed the onset of RNF43 mutations at different stages of human CAC development by exome sequencing, and...

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Literature Corpus work: 64a85536-472a-5985-b0ca-fb1d0cc3a0c6
DOI: 10.1101/2024.01.30.577936

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