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Article

Phenotypic Analysis of Mice with Conditional Knockout of PPP2CA in Colonic Tissues.

Digestive diseases and sciences - 1 Aug 2026

Liu Zhihan, Fang Chao, Li Jun

Abstract excerpt

OBJECTIVE: This study aimed to investigate the function and role of PPP2CA in the colon by analyzing the phenotype of colon-specific PPP2CA-knockout mice. PPP2CA is the gene encoding the catalytic subunit of serine/threonine protein phosphatases 2A (PP2A). METHODS: A conditional knockout mouse model was established using the Cre/loxP system. Physiological changes in mice were recorded after tamoxifen-induced...

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Cell Proliferation
Colon
Goblet Cells
Intestinal Mucosa
Protein Phosphatase 2
Protein Phosphatase 2C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41774332
DOI: 10.1007/s10620-026-09756-2

Genes

PPP2CA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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