Article
Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) mice.
Gastroenterology - 1 Sept 2014
Im Eunok, Jung Jane, Pothoulakis Charalabos, Rhee Sang Hoon
Abstract excerpt
BACKGROUND & AIMS: Early-onset ulcerative colitis, which is considered severe colonic inflammation that develops in infants and young children, can be caused by alterations in interleukin (IL)-10 signaling, although other factors are involved in its pathogenesis. We investigated whether loss of phosphatase and tensin homologue (PTEN), which regulates many important cell functions such as cell proliferation, cell...
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