Article

Partial loss of colonic primary cilia promotes inflammation and carcinogenesis

2019-12-20

Abstract excerpt

Primary cilia (PC) are important signaling hubs in cells and their deregulation has been associated with various diseases including cancer. Here we explored the role of PC in colorectal cancer (CRC) and colitis. In the colon we found PC to be mostly present on different subtypes of fibroblasts. Colons of mice exposed to either chemically induced colitis-associated colon carcinogenesis (CAC) or dextran sodium sulfa...

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Literature Corpus work: a50b9fe4-988b-51b5-9e38-553a4f07fead
DOI: 10.1101/2019.12.20.871772

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