Article
Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2021
Ho Yen-Ting, Shimbo Takashi, Wijaya Edward, Kitayama Tomomi, Takaki Satoshi, Ikegami Kentaro, Miyashita Kazuya, Ouchi Yuya, Takaki Eiichi, Yamamoto Ryoma, Kaneda Yasufumi, Tamai Katsuto
Abstract excerpt
BACKGROUND & AIMS: Proper resolution of inflammation is essential to maintaining homeostasis, which is important as a dysregulated inflammatory response has adverse consequences, even being regarded as a hallmark of cancer. However, our picture of dynamic changes during inflammation remains far from comprehensive. METHODS: Here we used single-cell transcriptomics to elucidate changes in distinct cell types and...
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