Epithelial dysfunction as a driver of symptoms in gastrointestinal disorders

Abstract excerpt

<title>Abstract</title> <p>The intestinal epithelium integrates host and environmental signals to regulate defense, absorption, and fluid balance 1-3. Single-cell atlases have unveiled regional specialization across the gut 4-6. Nevertheless, the colorectum, closely linked to chronic GI symptoms, remains underexplored. Debilitating symptoms such as altered bowel habits and abdominal pain hallmark irritable bowel...

Topics

Open a Topic to create a Post that cites this publication.

• Barrier Structure and Function Studies
• Cell Adhesion Molecules Research
• Congenital gastrointestinal and neural anomalies
• Digestive system and related health
• IL-33, ST2, and ILC Pathways
• Immune Cell Function and Interaction
• Pancreatic function and diabetes
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

0087b173-1ac1-5578-84ed-00bc9505e378

DOI

10.21203/rs.3.rs-7535904/v1