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Article

Genetic Mouse Models with Intestinal-Specific Tight Junction Deletion Resemble an Ulcerative Colitis Phenotype.

Journal of Crohn's & colitis - 1 Oct 2017

Stremmel Wolfgang, Staffer Simone, Schneider Mathias Jochen, Gan-Schreier Hongying, Wannhoff Andreas, Stuhrmann Nicole, Gauss Annika, Wolburg Hartwig, Mahringer Anne, Swidsinski Alexander, Efferth Thomas

Abstract excerpt

BACKGROUND AND AIMS: A key pathogenetic feature of ulcerative colitis [UC] is an intrinsic low mucus phosphatidylcholine[PC] content. Recently, a paracellular transport for PC across tight junctions[TJs] was described, suggesting TJ disturbance as a cause of diminished luminal PC transport. Therefore, we aimed to generate mutant mice with TJ deletion to evaluate whether a UC phenotype developed. METHODS: CL57BL/6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28575164
DOI: 10.1093/ecco-jcc/jjx075
PMCID: PMC5881657

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