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Article

Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiation

17 Aug 2016

Abstract excerpt

Motile airway cilia that propel contaminants out of the lung are oriented in a common direction by planar cell polarity (PCP) signaling, which localizes PCP protein complexes to opposite cell sides throughout the epithelium to orient cytoskeletal remodeling. In airway epithelia, PCP is determined in a 2-phase process. First, cell-cell communication via PCP complexes polarizes all cells with respect to the...

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PMID: 27570836
DOI: 10.1172/jci.insight.88027

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