Article
Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis.
Cancer - 15 Dec 2022
Pastore Friederike, Pastore Alessandro, Rothenberg-Thurley Maja, Metzeler Klaus H, Ksienzyk Bianka, Schneider Stephanie, Bohlander Stefan K, Braess Jan, Sauerland Maria C, Görlich Dennis, Berdel Wolfgang E, Wörmann Bernhard, von Bergwelt-Baildon Michael S, Hiddemann Wolfgang, Spiekermann Karsten
Abstract excerpt
BACKGROUND: Acute myeloid leukemia (AML) with initial hyperleukocytosis is associated with high early mortality and a poor prognosis. The aims of this study were to delineate the underlying molecular landscape in the largest cytogenetic risk group, cytogenetically normal acute myeloid leukemia (CN-AML), and to assess the prognostic relevance of recurrent mutations in the context of hyperleukocytosis and clinical...
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