Article
Genomics of Acute Myeloid Leukemia Diagnosis and Pathways.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2017
Bullinger Lars, Döhner Konstanze, Döhner Hartmut
Abstract excerpt
In recent years, our understanding of the molecular pathogenesis of myeloid neoplasms, including acute myeloid leukemia (AML), has been greatly advanced by genomics discovery studies that use novel high-throughput sequencing techniques. AML, similar to most other cancers, is characterized by multiple somatically acquired mutations that affect genes of different functional categories, a complex clonal...
Topics
- Genetic Testing
- Genomics
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Nucleophosmin