Article
Genomic structural variations contribute to inform prognosis in patients with cytogenetically normal acute myeloid leukemia.
Blood cancer journal - 6 Mar 2026
Bartalucci Niccolò, Mannelli Francesco, Tarantino Danilo, Enderti Alessio, Romagnoli Simone, Colazzo Daniele, Scappini Barbara, Gianfaldoni Giacomo, Piccini Matteo, Signori Leonardo, Irushani Fiorenza, Salmoiraghi Silvia, Ottone Tiziana, Piciocchi Alfonso, Vannucchi Margherita, Siciliano Maria Chiara, Boccacci Roberto, Orsi Silvia, Civini Alessia, Fazi Paola, Santi Raffaella, Vignetti Marco, Bortoluzzi Stefania, Bosi Alberto, Venditti Adriano, Rambaldi Alessandro, Voso Maria Teresa, Guglielmelli Paola, Vannucchi Alessandro M
Abstract excerpt
Cytogenetic and genomic profiling of acute myeloid leukemia (AML) guides personalized treatment according to ELN2022 recommendations. However, marked outcome variability persists among cytogenetically normal (CN-) patients, representing an unmet clinical need. We used long-read whole-genome sequencing to interrogate the prognostic significance of structural variations (SVs) in a prospective cohort of 162...
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