Hyperleukocytosis is associated with distinct genetic alterations and is an independent poor-risk factor in de novo acute myeloid leukemia patients.

doi:10.1111/ejh.13073

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Article

Hyperleukocytosis is associated with distinct genetic alterations and is an independent poor-risk factor in de novo acute myeloid leukemia patients.

European journal of haematology - 1 Jul 2018

Tien Feng-Ming, Hou Hsin-An, Tsai Cheng-Hong, Tang Jih-Luh, Chen Chien-Yuan, Kuo Yuan-Yeh, Li Chi-Cheng, Lin Chien-Ting, Yao Ming, Huang Shang-Yi, Ko Bor-Sheng, Hsu Szu-Chun, Wu Shang-Ju, Tsay Woei, Tseng Mei-Hsuan, Liu Ming-Chih, Liu Chia-Wen, Lin Liang-In, Chou Wen-Chien, Tien Hwei-Fang

Abstract excerpt

OBJECTIVES: Acute myeloid leukemia (AML) with hyperleukocytosis (HL) is intuitively thought as a unique group with dismal prognosis. However, comprehensive studies regarding the genetic landscape and clinical outcome in this group of patients are limited. METHODS: A total of 693 newly diagnosed de novo non-M3 AML patients were consecutively enrolled. We compared relevant mutations in 20 genes between AML patients...

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Identifiers

PMID: 29624746
DOI: 10.1111/ejh.13073

Genes

FLT3
NPM1
TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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