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Article

Identification of relapse-associated gene mutations by next-generation sequencing in low-risk acute myeloid leukaemia patients.

British journal of haematology - 1 May 2020

Prieto-Conde María Isabel, Jiménez Cristina, García-Álvarez María, Ramos Fernando, Medina Alejandro, Cuello Rebeca, Balanzategui Ana, Alonso José M, Sarasquete Maria Eugenia, Queizán José Antonio, Alcoceba Miguel, Bárez Abelardo, Puig Noemí, Cantalapiedra Alberto, Gutiérrez Norma C, García-Sanz Ramón, González-Díaz Marcos, Chillón María Carmen

Abstract excerpt

Recommended genetic categorization of acute myeloid leukaemias (AML) includes a favourable-risk category, but not all these patients have good prognosis. Here, we used next-generation sequencing to evaluate the mutational profile of 166 low-risk AML patients: 30 core-binding factor (CBF)-AMLs, 33 nucleophosmin (NPM1)-AMLs, 4 biCEBPα-AMLs and 101 acute promyelocytic leukaemias (APLs). Functional categories of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 32124426
DOI: 10.1111/bjh.16420

Genes

NPM1
DNMT3A
FLT3
IDH1
NRAS
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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