Genomic Classification and Prognosis in Acute Myeloid Leukemia.

doi:10.1056/NEJMoa1516192

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Article

Genomic Classification and Prognosis in Acute Myeloid Leukemia.

The New England journal of medicine - 9 Jun 2016

Papaemmanuil Elli, Gerstung Moritz, Bullinger Lars, Gaidzik Verena I, Paschka Peter, Roberts Nicola D, Potter Nicola E, Heuser Michael, Thol Felicitas, Bolli Niccolo, Gundem Gunes, Van Loo Peter, Martincorena Inigo, Ganly Peter, Mudie Laura, McLaren Stuart, O'Meara Sarah, Raine Keiran, Jones David R, Teague Jon W, Butler Adam P, Greaves Mel F, Ganser Arnold, Döhner Konstanze, Schlenk Richard F, Döhner Hartmut, Campbell Peter J

Abstract excerpt

BACKGROUND: Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical practice. METHODS: We enrolled a total of 1540 patients in three prospective trials of intensive therapy. Combining driver mutations in 111 cancer genes with cytogenetic and...

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Identifiers

PMID: 27276561
DOI: 10.1056/NEJMoa1516192
PMCID: PMC4979995

Genes

IDH2
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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