Article
Targeted deep sequencing improves outcome stratification in chronic myelomonocytic leukemia with low risk cytogenetic features.
Oncotarget - 30 Aug 2016
Palomo Laura, Garcia Olga, Arnan Montse, Xicoy Blanca, Fuster Francisco, Cabezón Marta, Coll Rosa, Ademà Vera, Grau Javier, Jiménez Maria-José, Pomares Helena, Marcé Sílvia, Mallo Mar, Millá Fuensanta, Alonso Esther, Sureda Anna, Gallardo David, Feliu Evarist, Ribera Josep-Maria, Solé Francesc, Zamora Lurdes
Abstract excerpt
Clonal cytogenetic abnormalities are found in 20-30% of patients with chronic myelomonocytic leukemia (CMML), while gene mutations are present in >90% of cases. Patients with low risk cytogenetic features account for 80% of CMML cases and often fall into the low risk categories of CMML prognostic scoring systems, but the outcome differs considerably among them. We performed targeted deep sequencing of 83...
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