Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic determinants of polygenic prediction accuracy within a population.

Genetics - 30 Nov 2022

Lu Tianyuan, Forgetta Vincenzo, Richards John Brent, Greenwood Celia M T

Abstract excerpt

Genomic risk prediction is on the emerging path toward personalized medicine. However, the accuracy of polygenic prediction varies strongly in different individuals. Based on up to 352,277 European ancestry participants in the UK Biobank, we constructed polygenic risk scores for 15 physiological and biochemical quantitative traits. We identified a total of 185 polygenic prediction variability quantitative trait...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 36250789
DOI: 10.1093/genetics/iyac158
PMCID: PMC9713421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic determinants of polygenic prediction accuracy within a population.PMID 36250789Read ↗

Significant sparse polygenic risk scores across 813 traits in UK Biobank.Semantic proximity Read ↗

Statistical genetics and polygenic risk score for precision medicineSemantic proximity Read ↗

Identifying and characterizing disease subpopulations that most benefit from polygenic risk scores.Semantic proximity Read ↗

Genetic risk prediction in complex disease.Semantic proximity Read ↗

Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseasesSemantic proximity Read ↗

Exploring the predictive power of polygenic scores derived from genome-wide association studies: a study of 10 complex traits.Semantic proximity Read ↗

Advancements and limitations in polygenic risk score methods for genomic prediction: a scoping review.Semantic proximity Read ↗

The evolution of genetic-based risk scores for lipids and cardiovascular diseaseSemantic proximity Read ↗

Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives.Semantic proximity Read ↗

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary diseaseSemantic proximity Read ↗

Clinical use of polygenic risk scores: current status, barriers and future directions.Semantic proximity Read ↗

Instability of high polygenic risk classification and mitigation by integrative scoringSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.