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Article

Clinical use of polygenic risk scores: current status, barriers and future directions.

Nature reviews. Genetics - 1 Mar 2026

Kullo Iftikhar J

Abstract excerpt

Genome-wide association studies have identified thousands of single-nucleotide variants that are associated with complex traits, including cardiometabolic diseases, cancers and neurological disorders. Polygenic risk scores (PRSs), which aggregate the effects of these variants, can help to identify individuals who are at increased risk of developing such diseases. As PRSs are typically only weakly associated with...

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PMID: 41073616
DOI: 10.1038/s41576-025-00900-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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