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Article

Single-Cell Chromatin Accessibility Data Combined with GWAS Improves Detection of Relevant Cell Types in 59 Complex Phenotypes.

International journal of molecular sciences - 28 Sept 2022

Das Akash Chandra, Foroutan Aidin, Qian Brian, Hosseini Naghavi Nader, Shabani Kayvan, Shooshtari Parisa

Abstract excerpt

Several disease risk variants reside on non-coding regions of DNA, particularly in open chromatin regions of specific cell types. Identifying the cell types relevant to complex traits through the integration of chromatin accessibility data and genome-wide association studies (GWAS) data can help to elucidate the mechanisms of these traits. In this study, we created a collection of associations between the...

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Identifiers

PMID: 36232752
DOI: 10.3390/ijms231911456
PMCID: PMC9570273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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