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Article

PLCG2 across human disease: genetic variants, signaling mechanisms, and clinical implications.

Journal of translational medicine - 8 Jan 2026

Jiang Ping, Wang Mingcong, Zhang Chengzhe, Li Xiaopeng, Wang Zhi, Guo Yajuan, Zhang Juhua, Yan Wei, Xi Xiaobing

Abstract excerpt

BACKGROUND: Phospholipase Cγ2 (PLCG2) serves as a central signal transducer within immune and neural lineages, catalyzing the conversion of membrane phosphoinositides into second messengers to regulate intracellular Ca2+ dynamics. By integrating inputs from B-cell receptor (BCR) signaling, TREM2-mediated microglial activation, and the NF-κB and Akt-mTOR pathways, PLCG2 coordinately regulates essential programs of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41507916
DOI: 10.1186/s12967-025-07632-7
PMCID: PMC12838089

Genes

PLCG2
BCR
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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