Article
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.
Molecular neurodegeneration - 6 Apr 2021
Magno Lorenza, Bunney Tom D, Mead Emma, Svensson Fredrik, Bictash Magda N
Abstract excerpt
The central role of the resident innate immune cells of the brain (microglia) in neurodegeneration has become clear over the past few years largely through genome-wide association studies (GWAS), and has rapidly become an active area of research. However, a mechanistic understanding (gene to function) has lagged behind. That is now beginning to change, as exemplified by a number of recent exciting and important...
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