Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predicting nicotine metabolism across ancestries using genotypes.

BMC genomics - 21 Sept 2022

Baurley James W, Bergen Andrew W, Ervin Carolyn M, Park Sung-Shim Lani, Murphy Sharon E, McMahan Christopher S

Abstract excerpt

BACKGROUND: There is a need to match characteristics of tobacco users with cessation treatments and risks of tobacco attributable diseases such as lung cancer. The rate in which the body metabolizes nicotine has proven an important predictor of these outcomes. Nicotine metabolism is primarily catalyzed by the enzyme cytochrone P450 (CYP2A6) and CYP2A6 activity can be measured as the ratio of two nicotine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cotinine
Share to Genome-Wide Association Study
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nicotine

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 36131240
DOI: 10.1186/s12864-022-08884-z
PMCID: PMC9490935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predicting nicotine metabolism across ancestries using genotypes.PMID 36131240Read ↗

Predicting Nicotine Metabolism Across Ancestries Using GenotypesSemantic proximity Read ↗

Genome-Wide Association of the Laboratory-Based Nicotine Metabolite Ratio in Three Ancestries.Semantic proximity Read ↗

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activitySemantic proximity Read ↗

Multiethnic Prediction of Nicotine Biomarkers and Association with Nicotine DependenceSemantic proximity Read ↗

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.Semantic proximity Read ↗

Transferability of Ancestry-Specific and Cross-Ancestry CYP2A6 Activity Genetic Risk Scores in African and European Populations.Semantic proximity Read ↗

Analyses of nicotine metabolism biomarker genetics stratified by sex in African and European Americans.Semantic proximity Read ↗

The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.Semantic proximity Read ↗

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.Semantic proximity Read ↗

Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk.Semantic proximity Read ↗

The Role of Pharmacogenetics in Smoking.Semantic proximity Read ↗

SNPs within CHRNA5-A3-B4 and CYP2A6/B6, nicotine metabolite concentrations and nicotine dependence treatment success in smokers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.