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Article

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity

27 Feb 2019

Abstract excerpt

The nicotine metabolite ratio (NMR; 3-hydroxycotinine/cotinine) is an index of CYP2A6 activity. CYP2A6 is responsible for nicotine's metabolic inactivation and variation in the NMR/CYP2A6 is associated with several smoking behaviors. Our aim was to integrate established alleles and novel genome-wide association studies (GWAS) signals to create a weighted genetic risk score (wGRS) for the CYP2A6 gene for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30815984
DOI: 10.1111/adb.12741

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