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Article

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.

PLoS genetics - 1 Jan 2015

Loukola Anu, Buchwald Jadwiga, Gupta Richa, Palviainen Teemu, Hällfors Jenni, Tikkanen Emmi, Korhonen Tellervo, Ollikainen Miina, Sarin Antti-Pekka, Ripatti Samuli, Lehtimäki Terho, Raitakari Olli, Salomaa Veikko, Rose Richard J, Tyndale Rachel F, Kaprio Jaakko

Abstract excerpt

Individuals with fast nicotine metabolism typically smoke more and thus have a greater risk for smoking-induced diseases. Further, the efficacy of smoking cessation pharmacotherapy is dependent on the rate of nicotine metabolism. Our objective was to use nicotine metabolite ratio (NMR), an established biomarker of nicotine metabolism rate, in a genome-wide association study (GWAS) to identify novel genetic...

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Share to Cytochrome P-450 CYP2A6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26407342
DOI: 10.1371/journal.pgen.1005498
PMCID: PMC4583245

Genes

EGLN2
NUMBL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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